Hi got a big problem, when autosave or save a game, the game always crash, what the hell is the problem, any solution

Have You tried 3 standard solutions?
1) Delete save folder and try to start new game (maybe save file is corrupted)
If it does not work:
2) Uninstall and re-install game
If it is still wrong
3) Try to repair system there could be some problem in it.

To be honest never had problems with D:OS, but hd similar problem with another games and mostly 1st solution help.