I found really nasty bug in Driftwood. After talking to Nicholas (npc on the on the ground between merchant and Magister's office) , who tells you about some stranger who healed him (it initiates or updates a quest), character makes a speach after which is unable to activate any kind of dialog including waypoints. I tried this with all the characters in my party and all of them were unable to activate any kind of conversation.
Only option that worked was reload the save, I usually make before most of the conversations, and avoid any conversations with that NPC.