BreezyBadger: A temporary fix is to uninstall the existing 2015 Visual C++ Redistrubutable and re-install the 2015 Visual C++ Redistrubutable (update 3, 64bit). Not repair, that doesn't work, re-install.
Do you have the same problem starting the Classic version of the game?
Are you getting a 0xc000007b error?
The Definitive Edition uses the 2017 Visual C++ redistributable. Try doing a manual re-install of that, if you haven't already.
https://go.microsoft.com/fwlink/?LinkId=746572 (direct download)
or
https://support.microsoft.com/en-ca/help/2977003/the-latest-supported-visual-c-downloads Is there any difference exiting out of Galaxy, if applicable, and starting the game directly from the '..\Divinity Original Sin 2\DefEd\bin\EoCApp.exe' program file, by right clicking and running as administrator (or '..\Divinity Original Sin 2\Classic\EoCApp.exe' for the original release)?
Try doing a clean boot and then test the game. Click Start, or hit WinKey-R, type in msconfig and hit enter; in the General tab, click Selective Startup, uncheck Load startup items (if required) and leave Load system services and Use original boot configuration options checked. Next, click on the Services tab, check the box to Hide all Microsoft services, then click the Disable All button (maybe make a note of which are currently enabled/disabled), then click OK and reboot the computer.
Run msconfig again to switch back to the normal boot configuration.
Try checking your system files:
- click Start, type cmd into the search box, right click Command Prompt and select run as administrator.
- type the following command and hit Enter
sfc /scannow
When that is done, type exit and hit Enter, then reboot your computer.
For more details, see:
https://support.microsoft.com/en-ca/kb/929833 If that doesn't help, please email supportdos2@larian.com with a dxdiag report (WinKey-R, type in dxdiag and hit enter, then when it finishes loading click on the 'Save All Information...' button and save the report somewhere handy), and quote or link to this topic. Also check the '..\Divinity Original Sin 2\DefEd\bin' folder for the gold.log file, and zip a few of the 'CrashDump' files together to include.