i have limited use of my right hand due to nerve damage. (yes, i was right-handed)

i more or less play mouse-only when it comes to action. i have to switch my good hand between mouse and keyboard.

is this doable?

I'm only few hours in but so far nothing indicates that it isn't possible to play only one-handed with a mouse. You do want to press Tab key to highlight things you can interact with but if u have a mouse that you could bind Tab key to would probably be nice for you.

As far as I can tell all the "action" in this game doesn't require reflexes of any kind whatsoever - it appears to be similar to an adventure game, so effectively 99% point and click. The 1% would be for the TAB key to highlight objects of interest, which isn't necessary anyway but could be nice if you want to avoid pixel hunts - in which case you could probably bind it to a mouse button (not sure if that can be done in-game, but if not should be possible with a third-party tool like autohotkey - but again since nothing appears to require reflexes, you could casually let go of the mouse and slap the TAB, although that might get annoying after a while I imagine).

I've only just started playing so cannot 100% confirm the "zero reflexes required" part - but from what I can gather so far, and from what devs have said in interviews, I'd be very surprised if that's not the case.

The only part where you need to be quick is using a healing item if you take damage and you are on your last bar of health/morale, but that can easily be done with a mouse.

So I'd say yes, there is no problem playing this game one-handed.

Maybe try AUTOHOTKEY.

Here a simple Script for AUTOHOTKEY so that you only have to press the fourth Mousebutton once and TAB is held.
Press again and TAB is released. Script is between the lines :)

-----------------------------------------------
; Tab to Mouse Left Side XButton1

XButton1::
Toggle := !Toggle
If Toggle
Send {TAB Down}
else
Send {TAB Up}
return
-----------------------------------------------

Do not copy the --- lines ^^

You can get Auto Hot Key there ---> https://www.autohotkey.com/

Procedure:

-Install AHK
- Open an editor e.g. notepad, notepad++ etc
- Paste above script into the editor
- Save the file as e.g. disco_auto_tab.ahk
- Make sure that the file is saved as an AHK file !!!
- Doubleclick on it
- Enjoy

If you want to to use other mouse buttons then replace XButton1:

- Mouse 5 : replace it with Xbutton2
- Middle : replace it with MButton

Check if your mouse doesn't come with a dedicated software/settings menu (like Logitech or other brands), there might very well be a way for you to assign the TAB key to the middleclick or rightclick (you only left click, right click has no use) and you'll be able to leave the keyboard entirely except when you want to put the game on pause to quit/save/reload (you have to press ESC to open the pause menu). Or if you want to use quickisave (F5) and quickreload (F9).