initialize error isndoe to data files corruption or wrong settings. You set game to winowed and fullscreen at same time. You set 1280x1024. This resolution is first reason to get such error.
Pay attention to numbers. 1280x1024 is larger than any resolution below 1920x1080. If you have some mobile/tablet display you probably have display resolution where vertical side lower than 1000.
1920x1080 is not enough too. Whatever reason you want 1280x1024 - you need 2k+ display.

You one more a user who dont know hat he did, do you? judging by same options set to opposite arguments.
Lower resolution to 1024x768, unheck windowed mode, set 60hz. Or opposite kee windowed, set windowed or by App in DXCFG and keep Default hz or set one that you have set on Desktop (since windowed is Desktop based).
Dont forget to start both configurators as admin.

Refuse to launch - Windows un-sefurity sh!t issues. Everything except UAC should be turned off permanently entirely. Disabled. Deleted. UAC otherwise should be set on default option. You just must NOT put anything to C drive. D/Downloads, X/Games/. Maybe X/Tools for gaming related 3rd party apps like CheatEngine/ArtMoney.

It is either bad Windows services fake security (and unsecurity in truth) or your failed at game settings or infomplete downloading by gaming clients (always validate the downloads in any clients or BitTorrent apps).

Reinstall everything if you have Galaxy or games on system folders.

Hi, when I start the game, I get an error popup with the error message
MEM_BAD_POINTER. Everything was working fine in December last year. I guess a Windows Update could broke something.
I have Windows 11 and I run the game as Admin and in compatibility mode.

Does anyone has an idea how to get the game running again?

first try to validate game in Galaxy is you use Galaxy and its build of the game.
add /Games/ and where you have Galaxy to exceptions of W.Defender. But you need have them out of system folders (no Program Files).