Hi!
When I click the game, it opens GOG, but not the game itself, nothing else happens.
Ive tried "run as adminstrator", turning off firewall and deinstall + install, run it in Clean boot mode (windows 11).

My laptop: Lenovo IdeaPad Gaming 3 15,6.
Setup: Intel® Core™ i5-11300H-prosessor
Nvidia GeForce RTX 3050-grafikk
16 GB DDR4 RAM, 512 GB SSD-lagring

Pls help me, im a pc noob:)

I have a different computer but exactly the same problem.
The fix mentioned on the troubleshoot page doesn't work for me, with that openSSL creation thing

1. check the log.
There is a file called log.txt in the installation directory and it should have been updated last time you tried to play the game.
If there isn't, you miss writing rights to that directory. Move the game somewhere where no special rights are required.

2. Check the windows event log. If the game crashed, there is an entry there giving you some idea about the reasons for the crash.

I run it on W11 + RTX3080 + 64 GB RAM + AMD 5090x without problems, not even using compatibility mode. The game is only in 2D, so it does not need special hardware or graphic card drivers, but just in case you can try to install the ddraw.dll from dgVoodoo2.

I had a similar problem, and after much experimentation, I seem to have fixed it by removing the following registry values;

Under [HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers]:
"C:\\Program Files (x86)\\GOG Galaxy\\Games\\Desperados Wanted Dead or Alive\\desperados.exe"

And under [HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers]:
"C:\\Program Files (x86)\\GOG Galaxy\\Games\\Desperados Wanted Dead or Alive\\desperados.exe"

Perhaps some compatibility flag got set that shouldn't have? Anyway, I can't guarantee that will work for anyone else, but that fixed it for me. If anyone else tries this, be sure to export those values from the registry editor before deleting them so that you can put them back if it makes things worse.