So this is the first time I've played this games and I was wondering... am I the only one that gets dizzy while playing it? I'll probably get used to it but right now it's insane :S

Also, I'm having a bit of trouble playing it with a M&K, will using a Joystick alleviate this?

You are not alone with the motion sickness. My dad never could play it. I found a joystick is easier to play with as you can move better.

If you get sick now, not sure if you will get better. Most people who tend to get motion sickness it's because of a chemical imbalance in there head that causes this.

Drimamine (a.k.a. Dimenhydrinate) is your standard motion sickness pill and it works for the videogame symptoms as well.

As for the controls, the mouse isn't near sensitive enough. If you don't have a joystick, try using just the keyboard. I know it sounds crazy, but that's how many of us did it back in the day!

Here is my setup:

Forward/Back/Side slide: W A S D
Turn & Pitch: NumPad 8 4 5 6
Slide Up/Down: Numpad / and 2
Bank keys: Q and E
Main fire: Left shift
Cycle main: NumPad 7
Secondary fire: Space
Cycle secondary: NumPad 9
Bomb: C
Flare: F
Rearview: R
Map: Tab

Obviously a good joystick could simplify a lot of these complex maneuvers, but I think with a little practice you'll be shocked as to how well you can use so many keys. It's really exciting when you get in the zone!

I'm also getting a terrible motion sickness from Descent. I can't play other games, too, such as Mirror's Edge, which makes me feel terribly bad.

One possible "fix" for this may be running the game windowed - it surely wasn't made with 22 inch screens in mind, which is my case. However, I don't know if that's possible. Does anyone have an idea?

Try being a bit fuirther away from your monitor. That I find helps.

Of course, but it is not always practical.

I know it's not always pratical but you gotta do what ya gotta do. When i went from a 14" toa 17" monitor to play D2, it took me some time to get used io the size. I now play on a 21" and it's easy.

Lots and lots of motion sickness issues are caused by FOV (field of view) issues. If a game has too wide or too narrow a view, and you're sitting too close or too far away, you can get motion sickness even if you aren't susceptible to it from other sources. For instance, Psychonauts makes me sick over long periods of play, but not most other games, or car rides. I don't even get seasick.

For a lot of games, you can't adjust the FOV, but you CAN sit further away, which almost always helps, even if it doesn't get rid of the problem completely. It's become more of an issue in recent years for PC players of console-based games, because console games are designed to be played on a TV that's usually halfway across the room. When you sit 18" away from a huge computer monitor, you can get motion sickness or headaches, for the same reason you feel weird when you wear wall-eye glasses.

Took me some time to get used to as well. For me it was just time. I think anything you expose yourself to over time it should get easier, unless its a severe case. Its the same for me with roller coasters, first few times are rough, but the more i get on them the less motion sick i tend to get. The first few rides at six flags, are entirely different than the last few in a season. You obviously dont want to over expose, i would just try whats comfortable, even if its only a few minutes and go from there.