has any one run into this problem with descent 3 on windows 10

Not me and I'm on Win 1064bit and D3 runs fine.

the trouble is main.exe to bebroken
if i tryingto runi get asame troble asyou do i dont know how to fix that

Have you guys tried running the game as Administrator?

Are you using the GOG 1.4a version? Try switching from nGlide to OpenGL or vice versa. If using OpenGL apply the 32-bit patch available here: https://sectorgame.com/d3/downloads/?nav=display&file=864

Also try tinkering with command lines. This is my setup running OGL:

-width 1920 -height 1080 -aspect 1.78 -usesmoothing -nomultitexture -himem -hividmem -subpixelcorrect -nocompress -nointro -nooutragelogo -nosparkles -nomotionblur -z32bit -framecap 60

Adjust accordingly, also setup a profile for D3 (main.exe) in your nVidia control panel if you're using a Geforce. Something like this:

Yes i always run my games as Administrator Sorry this didnt work either. but thanks for trying still looking for a solution though

Apologies for the semi necro of this thread, but I just encountered that error. Bought the game in the recent sale, set the game to use 1280x960 res, and selected "new game". The video didn't load (showed a stuck menu) but the audio did, then I hit escape and the level started okay.

When I aborted the tutorial I was taken back to an unresponsive menu, when I alt-tabbed out of the game to kill it I found the error dialog you had.

When I clicked okay, I got another of those dialogs, then clicking ok again it close and that was it.
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I haven't tried the other suggestions listed yet, but I was running the game through the Galaxy launcher.
Win10 64Bit latest update (i7 4790k 4.4Ghz, 16GB Ram, NVidia GTX 1080ti)

Do you guys run the setup in the launcher?

Yes I did.

Just tried again with NGlide set to Vulkan rather than automatic, and game ran fine although I couldn't use 1280x960, I had to use 1024x768.

No error dialogs when I quit.

Sorry it's taken me long to reply, busy life.
Have you tried using command line options to set the resolution?

Not a problem, totally understand. I've been a different OS the last few days so no I haven't yet tried the command line arguments, will give them a go later today.

Had a chance to properly sit down and try running the game with the command line arguments. Had a mixed bag of results. I've uploaded some images to Imgur https://imgur.com/a/acdDl

If I set the output device in Setup to use OpenGL, and supply the arguments listed above (and using the 32bit patched main.exe) I get:

1) A tiny gameport window with the text shown at the top of the screen (image 1 & 4)
2) The menu uses the normal 4:3 ratio (a good thing) (Image 2)
3) Its a bit darker than using 3dfx
4) The mission intro fly-by runs at a widescreen ratio using the full 1920x1080 (Image 3)

If I swith the output to use 3DFX, and set nglide to use the Vulkan backend:

1) The arguments are ignored and game runs at default resolution

If I use 3DFX output, with nglide set to Auto backend I get:

1) The game menu is squashed into a widescreen res and the text looks awful
2) The game now fills the 1920x1080 space however the bottom of the UI is chopped off (and the text looking iffy) (Image 5)

So is there anyway to get the OpenGL version to actually fill the viewport rather than be a tiny window?

Try pressing the + key (on the number pad) to increase the view port size. That should go all the way after several presses.