Deponia

Works fairly well in Wine, just install and play.

Personally I got few minor problems, the first problem was that the game seldom stops responding for some seconds. The time is from one or two seconds (barely noticeable) to 15-20 seconds (rare and very annoying).

Another problem was at the end of Chaos of Deponia, many textures become rendered in pure white and dialogue audio line are missing. The effect is that it is impossible to understand what is going on since subtitles run too fast.

Yes, it works with Wine, but that bug you mentioned (unresponsiveness) progresses as you play, until it becomes too bad, and you need to exit the game and run it again to remove it. Sometimes exiting the fullscreen and returning - helps to bypass it as well,

I noticed that CPU utilization spikes for Depoina in those cases (which causes unresponsive behavior).