JudasIscariot: AFAIK I think it's mostly the amount of time you had that quirk on the character although don't quote me on that since 90% of the game is RNG-biased :P
Skive83: Okay :D ... so I guess it's almost impossible to get your characters out of negative quirks... Just gotta stick with the ones who I can live with. Okay, I mean I don't aim for getting rid of all neg quirks, I think that is part of the characters as well as the positive quirks?! I already fired some of my earliest characters, because they had 5 red skull negative quirks wiht very unsuitable habbits :D
You can get rid of them completely either via the Sanitarium or by using holy water on eldritch altars (the tentacle loooking ones) or on troubling effigies or by using holy water on a confession booth :)
The quirks you REALLY want to get rid of ASAP if you have a good hero are Kleptomania (they will steal the loot out of the chests you find in the dungeon), Sitomania (eat more food during runs), Curious (they will investigate curios more often and not let you use a supply item which can be really bad on some curios)
