Guys today GOG has updated my game with the 1.5 update hotfix and nothing doesn't start me the same I get to the final loading screen I press continue and it crashes even loading a much older save, what can I do? I don't feel like restarting a game that I almost finished after 120 hours.
Sorry for my bad english.

Have you tried verifying the game and updating graphics drivers? they added a new rendering tech into the RTX pipeline with the Hotfix mine was odd until i got the new Nvidia Drivers. They also no longer support the Nvidia 700 series GPU's and will soon stop supporting windows 7 in future patches.

I re-downloaded the game I updated the video card drivers and re-checked the files, I deleted all the mods installed, I followed the online guides but nothing the game crashes, if I start a new game it works correctly, but I can't start a new game after 120H, 60 € of game thrown down the toilet.
I have a GTX 1070 with an i7-4770k, audio driver realtek

1. Locate the savegame files in your hard disk and make a backup.
2. Delete savegame files
3. Start the game (not from GOG Galaxy. Execute the EXE in the game folder). The game will start as if you had just installed it, without any saved game.
4. Play for a while and save the game.
5. Exit the game and replace the files with the ones you had in copy.

See if that solves the problem.

For some reason, it is possible that the savegame files have been corrupted.

I think they are re-thinking their strategy. If they change the system requirements for a game after selling millions of copies, they will be sued into extinction.

But I can't lose my saves just by updating a game, it's absurd, I haven't installed any mods, but if I start a new game the game starts normally, I can't throw 120H in the toilet

Unfortunately, savegame corruption can happen with any game. It is not common, but it can happen. Most people have updated CyberPunk 2077 without problems. You just got unlucky. The only problem with 1.5 update is related to audio Nahimic service (audio software) that can be unloaded to run the game properly.

I usually do a manual backup of my games from time to time as a precaution.
For now, try to do what I have explained to see if you can recover the game progress. Otherwise, the problem may be something else.

I followed your step by step guide but nothing the result is always the same .... I'm going crazy

have asimilar problem, can not start the game brings always up that the game crashed.. Reinstall dosent work..