I'll try to keep it spoiler free as much as possible:

There's a mission called EPISTROPHY that has 7 smaller missions, the one called

EPISTROPHY: RANCHO CORONADO

is bugged and impossible to complete, at least for me. Which makes the main quest impossible to complete.

After you talk to the quest NPC you are supposed to do something, you do the thing but quest NPC disappears. Quest doesn't fail the dialogue you at at the begginning starts to loop with no NPC around.

If you're on that group of missions make sure to save before every step of it so you have something to fall back to.

PS: for the love of all that is holy please add an option to shut the damned phone off or something, for some reason literally everyone in the city knows who V is and they love spam calling as I drive somewhere or in the middle of a quest dialogue and everything scuffs. We have the mission markers on the map anyway why the mad phone traffic? <3