My screen's native resolution is 2560x1440 but that doesn't appear in the config screen when the game launches. What's the best way to get the game to use that resolution?

Edit: subject should say 1440p, sorry.

Adding your resolution manually in the config file should work.

"...\Documents\BloodRayne2\settings\rayne2.ini"

Yes, that got it, many thanks. Specifically I replaced two lines in the [Graphics] stanza thus:

[Graphics]
gamePIXX=2560
gamePIXY=1440