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Rotating the cam with the mouse in the direction of another monitor, results in the mouse slipping out of the game onto that monitor and after pressing a mouse button the game minimizes to tray. This makes the game unplayable with mouse+keyboard.
This question / problem has been solved by dr.schliemannimage
You could try Dual Monitor Tools.
This is a set of tools for multi monitor users that doesn't even need installation (you can choose to download the portable version if you don't want it to be installed into your system). One of the tool should be able to lock your cursor to a single monitor.
I'm using CursorLock. It's a small program that creates shortcuts which lock the cursor on the screen the program is running on.