Blood source has never been released, thus a proper source port is currently impossible.
Anyway there is a total conversion named "Blood Crossmatching" which uses the eDuke32 as a port of the Build engine. You can download it here.
Problem is the project is still in development: the total conversion has not been completed yet. As far as I know, the final boss in the fourth episode of the game is still missing, and the addons (Plasma Pak and Cryptic Passage) haven't been converted at all.