Tajasaurus: Has anyone tried with a PS4 controller?
Yes, I'm currently using a PS4 controller and it works perfectly just straight out of the box. Normally with these kinds of games you need to run something like DS4Windows to trick the game into thinking it's an Xbox controller but there's absolutely no need to do that at all with Blood Omen, the PS4 controller just works.
HOWEVER, note that if you install Verok's patch, it seems to break this native PS4 controller support, so you WILL need to run something like DS4Windows if you want to use your PS4 controller.