I'm using Debian 10. I've already tried to compile and install libjpeg.so.8 manually but still ScummVM that comes with the game does not find it.

Have you found any solution?

Have the same issue on Fedora 31.

So far it's enough to run a standalone version of scummvm and add the game from the installation directory. But since the scummvm says it's not fully supported I expect I might run into problems later.

If you don't mind me asking, what do you mean by "the scummvm says it's not fully supported"?
Is there a specific warning message you're seeing?

Thanks for your reply. Which Scummvm version do you use?

I've finally managed to run the game, following the advice from mnietek. For me it worked with the latest version of scummvm.

I use:
$ scummvm --version
ScummVM 2.1.0 (Oct 16 2019 00:00:00)
Features compiled in: TAINTED Vorbis FLAC MP3 ALSA SEQ TiMidity RGB zLib MPEG2 FluidSynth Theora FreeType2 JPEG PNG cloud (servers)

$ sudo dnf info scummvm
Ostatnio sprawdzono ważność metadanych: 0:41:17 temu w dniu czw, 19 gru 2019, 08:57:55.
Zainstalowane pakiety
Nazwa : scummvm
Wersja : 2.1.0
Wydanie : 1.fc31
Architektura : x86_64
Rozmiar : 75 M
Źródło : scummvm-2.1.0-1.fc31.src.rpm
Repozytorium : @System
Z repoz. : updates
[...]

And I get the folowing warning (see attached screenshot) when launching Blade Runner with restored content.
But I played the game for some time already (about an hour) and so far no bugs.

Oh, and I downloaded the file with subtitles from the ScummVM homepage. You need them for in-game subtitles to work.

The warning is normal for now. The restored content mode is work in progress, it is not yet complete (hopefully within next year!) and has not gone through extensive testing since the focus was the original game mode.

Still, the game is quite completeable in the current restored content mode

Somehow gog didn't include required libraries in this release although it used to with other SCUMMVM-based games, so it's a bit of a hassle to get them all on non-Ubuntu systems. You need to use ldd on scummvm_x86_64 to find what you are missing and then either install the libraries using system tools (like apt-get), put them in /usr/local/lib64 or similar, or edit the launcher scummvm to uncomment LD_LIBRARY_PATH variable initialization (of course, it needs to point to the right place). It's a bit of a quest to even start an adventure game!

If you install them libraries system-wide you shouldn't need to edit LD_LIBRARY_PATH. But it's hard to find the exact version the ScummVM engine embedded with the linux version is looking for, especially if you want to use the official repos for your distro and not some shady sources run by someone you don't know at all.

I had similar issue today

My solution - download & install ScummVM from official website

[i]wget scummvm.org/frs/scummvm/2.1.0/scummvm_2.1.0-1_debian10_amd64.deb
sudo dpkg -i scummvm_2.1.0-1_debian10_amd64.deb[/i]

Then in game files edit "support/gog_com.shlib" and change path to scumm in line 170 to look like this:

[i]run_scummvm() {
local conf="${1}"
scummvm -c "${conf}" --themepath=scummvm -n
}[/i]

That's all, now you can run ./start.sh as usual :-)