The Tweaks mod actually might be worth considering for a first playthrough as well. There's a couple of convenience options (namely the larger stacks of ammunition) which are great, and it can silence the "You must gather your party..." guy, which I'm sure you'll end up taking sooner or later.
The big tweak I like though is two multi-class changes. The first is allowing Fighter/xs to achieve GM in weapon proficiency, the second is removing the weapon limitations of Cleric/xs. To me, the first one is HUGE and goes a long way towards making multi-class a viable alternative to dual-class. That makes Jaheira much more appealing, as well as guys like Montaron and Coran in BG1. The second tweak isn't as important but it makes classes like Cleric/Thief and Cleric/Mage less annoying, especially as the former can now use shortbows, and the latter can at the very least use darts.