The EE doesn't
need any mods.
It already comes with the bug fixes that used to be provided by the various Fixpacks, the BG2-engine-features-for-BG1 that were provided by EasyTutu and BGT, the screen resolution support that was provided by the Widescreen Mod, etc. So those mods are no longer applicable.
There are lots of optional mods, of course.
From the ones recommended in the stickied "Baldur's Gate 2 essential mods" thread, the following are still relevant to the EE:
*
BG2 Tweak Pack -- It worked fine for me on BG2:EE version 1.3. It is currently being refactored and re-released as "
Tweaks Anthology", and even though that's still in beta it's probably the safer choice for game version 2.x.
*
Unfinished Business -- Latest version is fully compatible with BG2:EE.
*
Banter Packs -- Latest version is fully compatible with BG2:EE.
My recommendation for a first-time player is this:
Install Unfinished Business if you are a completionist who values every tiny side quest, otherwise skip it.
Do
not blindly install the Tweak Pack, which contains a huge number of controversial and weird components. You may want to install a few carefully selected components from it though, for example if you hate inventory management you could install the "Bottomless Bags of Holding" and "Unlimited Ammo Stacks" components. They're effectively cheats, but hey, it's a single-player game.
There are many other BG2:EE mods I really like, such as various quest mods, Spell Revisions, SCS... but I wouldn't recommend them for first-time players. They more for increasing the game's replayability and challenge for returning players.