A lot of good advice here, but the thing that I disagree with on a playstyle preference is sacrificing how you actually want your characters to be for ease of combat with the idea of "hey just use these builds and it will be way easy." Yes, of course, there are combat mechanics and things to learn to not screw yourself with making a character, but really, I find all this "do it this way" advice to be misleading. Do it how you want, it really should be relatively easily doable once you learn the game style a bit. But however you want to do it, follow these guidelines:
1.) Have a balanced group, and get 6 asap. Not too many casters, not too many fighters, a few ranged (and then have them use different weapons), a few melee (choose different weapons and have shield/no shield combinations), a very good healer or a 2 semi-good healers with other good qualities, someone to find traps and unlock things (though even this isn't necessary.) Use them as HP sponges. Positioning is very important. Taking a fight to a different room with a doorway or getting out of a hallway to have more freedom to move is frequently very crucial to making a difficult encounter quite a lot easier. Don't be afraid to retreat. A LOT. Take that character who only has 1HP left that 2 guys are attacking and RUN THEM FAR AWAY while focus-firing with all of your others to pull the attackers off. Rinse repeat until you've won. Even if you are only fighting with 1 character at the end vs. 3 while all of your other chars are across the map nursing wounds, you will very frequently win if you just use all of your characters' to absorb some damage at one point or another.
2.) Use all the spells, potions, and other usable items you have/find liberally. Then buy more and use them liberally. Pretty fast in the game you have enough wealth accumulated to buy 20-50 health potions to last you long enough until you have enough money and items that you'll never really be stressing for healing except in a timely manner in the heat of battle, as it should be. Cast your heart out until you learn what is unnecessarily too much.
3.) If something is too hard, go somewhere else and do something else and gain XP a bit then come back to it. This was probably my #1 mistake early on in my cRPG life. I'd get too far ahead too fast, missing content and therefor XP that was vital to a noobs enjoyable success. There's almost always something that can be being done to gain enough XP to lvl a character or 2 before you HAVE to have a combat encounter that may be a little difficult and have to sweat through it.
3.) Read the manual's combat section.
4.) And for your caster's sake, always have on stoneskin.