I had a bit of trouble getting into it at first as well, due primarily to the nature of the combat. In fact, I just bought the GOG.com version since they were running it cheap, and am still having a bit of trouble getting past the early parts. Still, I'm doggedly persistent because I just know the story is one that I could fall in love with. So here are a few things I've started doing that are making it a bit easier, and hopefully they'll help you out too:
-When making a character, stick to tech or magic, don't try to mix them. The manual tells us that if a character has a high technical aptitude, then any spells or magical items used by that character will be considerably less powerful and much more prone to critical failures. The same is true of the converse (magical character using tech items).
-DEFINITELY switch to turn-based combat. It's much easier to control, especially if you're like me and like to be tactical in games like these.
-Magic is apparently easier than tech if you're just starting out (but less interesting if you ask me; you can't conjure up a giant clockwork spider :P)
-There's an
unofficial patch that is apparently highly recommended, as it fixes a lot of bugs, attends to some balancing issues, and unlocks some content or other. I can't speak for it, as I just downloaded it and haven't installed it yet, but it has apparently helped a lot of people with their experience with the game.
-Lastly, SAVE COMPULSIVELY. I'm really terrible at saving games, and Arcanum is absolutely punishing me for it. Every time you finish a combat, go into a new area, or get ready to open the world map, save your game. In fact, do it more often than that. Make it a habit. EDIT: The F7 key is the auto-save key. It is now your best friend.
Hope this helps you out. If you come up with your own solutions, I'd love to hear them from you too!