Well, every job you do for Madame Lil raises her disposition slightly whether you take money or a girl as payment. Get it high enough and seek out her training, and she'll tell you where to locate the master trainer for persuasion as well as roughly when in the plot to seek him out. She also tells you about the sewer dungeons in Tarant, in the process of giving you the quest for one of the most useful magic items in the game which you can either keep or give to her and later steal. Furthermore, her brothel is the unacknowledged social hub of Tarant. Kill her or one of her girls, and pretty much all of Tarant will hear about it and get pissed off even if noone actually witnesses it. Madame Lil's also adds a chance to get a... Unique reputation modifier. Also, it's a great way to make cash early on, though getting the payment in cash response as a male character can be kind of tricky and may require downloading the unofficial arcanum patch mod.