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Will my sword and shield character get smoked by gun toting enemies later in the game? You've heard of bringing a knife to a gunfight, right?
Nope. Not at all.

In fact, guns are fairly underpowered (well, most things are underpowered compared to the PC late in the game). Magic is the real powerhouse of the game (but again, don't worry too much if that isn't your cup of tea as there are only a couple enemies that really will use magic effectively and damagingly on you).

If you go for gun toting in a later build though you also won't necessarily find yourself underpowered - as I said, it is a lot about the PC being really powerful throughout the game. Guns are good, the number of NPCs that have good guns though is low, and when they do your character is almost certainly going to have equally good/better armor and weapons and skills.
Thanks