Once I get to Brazil I can no longer save the game.

I can access the save menu, but when I click on an open (or used) save slot nothing happens.

Yes, it seems this is happening to everybody. You can still save the game using quicksave, though (F9 to save, F12 to load).

And Autosave is also still working. But I agree, it's an annoying bug.

i have the same problem any idea?

I have the same problem, my Autosave is not working.
Can someone give me a save file for beginning of chapter 7 (or chapter 6 so I dont have to replay from chapter 4). I'm on a Mac and PC saves seem not to work.

Same problem here.
I couldn't save the game from the latter of chapter 6.
It's really a shame because game itself is awesome.

same problem here :(

You can work around this by quitting the game. Then when you restart it choose Continue from the main menu.

Same problem here... in Chapter 6 Part 2 :(

Same here.

I also had an issue with the bomb defusing puzzle, I guess the "skip" button is a sort of "workaround". Did the guys at GOG test it before selling it?

I won't even bother to ask the same about Daedalic: apart from the graphics, the game is bad. Bad voice acting, boring and slow-paced story, illogical puzzles, and a load of unnecessary eco propaganda. Never again.

same here, but my autosave still work

Yup, apparantly this bug is still present in the patched version, even though I just found out that it was already reported on the German Daedalic forums back in December 2012, and the moderator said he passed it on and expressed his hope that a solution would soon be found ...

It's also a pretty grave bug. I was grateful to learn that the Autosave still works, because nothing kills the fun in a point and click adventure faster than a tour de force against one's will; the puzzles become a chore and the dialogues annoying if you really just want to go to sleep, but you have to stay up all night to finish the game in one go. ;)

Can't save anymore, can't quicksave, no autosave...
Apart from that, the technic (?) in the game is horrible. Sometimes I can't klick at objects, so I have to leave the place and go back. Some cutscenes were played twice after revisiting special locations.
To sum it up, this game is a big disappointment for me.