Sometimes it does take a while to adjust to a different game.

The time I most recently notice this was going from Ys Origin (IIRC, I could be mistaken) with a side of Crimzon Clover to Elminage Gothic.

Here it wasn't the controls that were different, but rather the fact that the gameplay is completely different. The Ys games and Crimzon Clover are fast paced games that use collision-based combat and where dodging is a huge part of the gameplay. (I could argue that bullet hell games are largely based on dodging rather then shooting.) Elminage Gothic, however, is a turn based game like the early Wizardries and is therefore much slower paced. No dodging needed here because the game uses dice rolls rather than collisions to determine whether attacks hit.

So, that took a bit of an adjustment, but afterwords, I was able to enjoy the game.

I have had control related issues before, but I can't remember any off hand.

Actually, it sometimes happens when playing PlayStation games. Japanese releases and early US releases use O for confirm and X for cancel, but for most US releases it's the other way around.

I guess I could also say the same for Wasteland. I keep getting in the mindset that I'm playing a Fallout style game where when you boil it down, it's more like Might&Magic and Wizardry RPG wise.

Also that's my issue with Dragon Quest 8 for PS2, X is cancel while O is menu/command, while usually it's the other way around.

X to cancel and O to confirm are usual settings for Japan. Other way around - for Europe/America.

Sometimes this rule is forgotten when game is being localized. Final Fantasy VII has Japanese controls, Final Fantasy IX - NA/EU controls... I remember Dragon Quest VIII having very awkward controls, hence this game is deep in my backlog.

Daggerfall uses right mouse button to attack and left button - to interact, Morrowind has entirely different controls. It results in random NPCs dying because I swing the sword instead of starting the talk...

Also, my biggest problem with the differences between M&M and Wizardry 6 is that M&M relies entirely on the keyboard while Wizardry relies almost entirely on the mouse. THIS is what throws me off the most.

And yeah, I'm still hoping that someday DQ7 and 8 will be localized for 3DS in North America (Seeing as a spin-off game has been officially announced, gives me hope) Even then, even if they were announced soon it would still be years before 8 makes it over here, as they would localize 7 first, then wait a few years for 8. And by then I'll have beaten the PS2 version regardless.