Delixe: I can think of at least 5 games that are more anticipated.
Call of Duty: Black Ops - Even Activision have played down their expectations for this one. It's by Treyarch and doesn't have Modern Warfare in the title. That's going to seriously confuse MW2 fans and it will probably be weeks before they recover enough cognitive ability to buy it. By then it will no longer be the latest game though. So it won't be bought. By anyone.
Medal of Honor - There's been quite a bit of interest in this one. Don't know if it's Halo beating interest though. Especially seeing as, again, it's shamelessly trying to cash in on MW's success by combining serious military-esque action with... Linkin Park.
Need for Speed: Hot Pursuit - The series hasn't been all that great since Underground 2 and now that I think about it, even that one was a bit iffy. I'd be surprised if anyone was jumping up and down with sheer excitement at the thought of playing yet another addition to the overly milked series. But you never know.
Fallout: New Vegas - It will sell well, I'm sure. Certainly well enough to keep Obsidian's foot in the Fallout door. Which is the kind of break they need after the abysmal reception Alpha Protocol received, and Sega's subsequent canning of the IP. But the only people really hyped about NV remember the Black Isle RPGs.
DC Universe Online - This is the first I've heard of it. I don't know, but that might not bode too well for the hype-o-meter.