Aliasalpha: A Who game pretty much has to be an adventure with a possible lean towards platformer (but a GOOD platformer) that only happens sometime. There's a LOT of running and a point & click would have trouble with portraying that but an exclusive platformer wouldn't work either, it'd just be a platformer with the licence spra painted over the top, "Who Raider" if you like...
Well, there are reasonably good games which still riff on the old Tomb Raider formula, namely Uncharted and Uncharted 2. With the right sort of level design, an adventure-platformer sort of game based on Dr. Who could work. On a console like the Wii, as someone else pointed out, this sort of gameplay could be combined with using a Wiimote as a Sonic Screwdriver...er, maybe?
Aliasalpha: An MMO could only be UNIT vs everything else, that or a horde of timelords and have it set in the time war and you know you'll lose in the end because the doctor is going to stop the whole thing
That's what I was thinking too, but I have no idea how it wouldn't just come off as another rip-off of every other MMO out there. If we're going to have everyone being a Time Lord, they'd have to think of some way to keep the game balanced. It almost reminds me of Star Wars Galaxies, when they made it easy for anyone to become a Jedi Knight. We'd of course also have ship-to-ship combat, in which case it'd come across as being like EVE or STO but with Time Lords in TARDISes against Daleks or Cybermen.
After diving headlong into Gabriel Knight I can't help but wonder if the only kind of game which would be true to the spirit of Dr. Who would be a (point-and-click? Heh...) PC adventure game, and we all know how economically hot those kinds of games are.
If we do see a single player DW game, I'd like to see us being able to take control of the Doctor's companion too; it'd add an extra interesting bit of depth to the gameplay (like being able to enter and explore places the Doctor conceivably couldn't).