dtgreene: It's not just sexuality that the SaGa series handles differently. Take everything you know about JRPGs and turn it on its head; depending on the game you get things like non-linearity, no experience points (instead, you get different growth systems, with SaGa 1, SaGa 2, and SaGa Frontier using different growth systems for different characters in the same game), spells being cheaper than physical attacks (SaGa Frontier 2 does this, for example), and other things that are just *different* than what most players are used to. (In fact, I believe Unlimited SaGa (which I own but haven't got around to actually playing) is even more unusual (does it have any LGBT characters?).)
Darvond: Don't forget about weapons with limited uses unless you've got a robot laying around or eating meat to change your party members if you picked a monster member.
Or SaGa 3's approach where you can change anyone into a monster just by eating enough meat, or into a robot by installing robot parts. (Interestingly enough, that game's remake, unlike many other remakes, is more complicated than the original, and it ditched the Level/XP system that the original (and most RPGs, for that matter) had.)
Then there's Romancing SaGa 2, in which, if your main character dies, you get to choose a new main character.
That's another thing about the SaGa series; choose two games in the series, and they will likely be very different.
Also, don't forget that early SaGa games have nukes, and SaGa 2 has the questions of whether Dunatis and Neptune exist. Closer to the topic, SaGa 2 actually has a wedding in it, but not all is well. SaGa 1, on the other hand, has some rather disturbing events; the end of the third major world is just the beginning (not what you are expecting from an old Game Boy game).
Seriously, I would recommend that any RPG fan who is able to do so to play through as many SaGa games as you can.