Is there any guide how to play this game? After fourth day I have best doctors, I am second/third in effectiveness of healing people, but I am the last in the patients opinion ranking and they are avoiding my clinic ... What am i doing wrong?

I'd like to know how to even make it through the first day!

All the guides on the net a useless, very contradictory, and don't even fit the game as it is offered here.....

You're welcome.

Can't say that I had the same experience though.
Haven't played in quite a while - still waiting for GOG to finally add and make the disk version available - but I do remember NEVER having followed any sort of guides or walkthroughs in the past. And ALWAYS managing to scrape by for a couple days without any real problems, while only relying on my own faculties and intuition.

Check the happiness of your customers!
Upgrade your Entrance Room (luxury version+ redline poster is enough) and a 145+ boobsized Nurse at the desk, then check out how the happyness of the waiting patients starts growing. Let them sit there (60-80 min i do), you can do this to max. male patients easier to reach up to 100% by this they enter the doctor with 80%-100% happiness
You can do the same in the waiting room, Booby nurse doing striptease all the time and the happiness keeps rising, somehow on male patients sometimes +5% by one jump ( 1 jump every couple of seconds)