Estelline: Sadly, this Hotfix didn't solve my insane ctd problems again (which started to appear with a hotfix in Dezember).
crispyflakes: Have you tried to downgrade your game back to a version before the hotfix in December?
Having this game with GoG allows us to do this vs. Steam, where you are stuck with most updated version.
edit: If you saved the previous Install files
Thanks for the advice, I already tried this. I can go all the way back to the version from December 7th, but even that one crashes constantly. I also ran dxdiag and msched, but my system found no problems. Completely re-downloaded, re-installed, checked for errors via Galaxy, tried to disable the launcher, updated all my drivers, cleared my cache and shut down my anti-virus software and all other passive programs that ran in the background. Nothing reduced the crashes.
Some people in the official Larian forum also mentioned how this only started happening to them after they played quite a lot of hours of BG3. There's a thread where people describe the same problem I have as early as in September. I honestly give up at this point. Been playing PC games for around 20 years but never had such trouble with any game.