TwoHandedSword: Spoilers ahead . . . as if you didn't know.
I'm going to assume you know how to get the blessing itself; if not, there are guides online.
The blessing gives you a +30 bonus to both DR and MR, an extra 100 to HP and Fatigue, +4 to DX, and 3 ranks (or as the game calls it, a +12 bonus) to each of the following: Melee, Dodge, Persuasion, Pick Pockets and Firearms.
So, assuming your max DX is 20, you want to max out at 16* (including your gauntlets or rings of dexterity). You'll also want to stop at two ranks of Dodge, Melee, Persuasion, etc. Don't forget that the full Persuasion benefit relies on having a high enough Charisma, just as Firearms is tied to Perception.
So how do you play the game till you get to that point? My favorite trick is to take the Professional Knife Tosser background and use Throwing as my attack of choice. The extreme bonus (3/4 of a full rank) means that I can achieve mastery in Throwing with a DX of only 15.
*Don't forget to factor in the one-of-a-kind Vivifier, which gives you a permanent +1 bonus to every stat. If you're determined to maximize everything, be sure to stop at 15 DX (and 19 ST, etc.) Or you could just install the level cap remover, and never worry about points again.
Thank you. Your post was really great and informative. You couldn't have done better! Thanks a lot :D
p.s Do you know how can I reach the vendigroth ruins before doing the storyline??