Hey
I have recently upgraded to the gtx 1080 and decided to jump back into the game. I can loadup my saves and fast travel without any issue what so ever yet when i die and am forced to reload a save the game either loads incredibly slowly or simply never loads at all (This happens the majority of the time) I don't have any mods installed only the Reshade e3fx mod. Any idea's? thanks :D

Try it without Reshade e3fx mod and see if it still happens.