I have a computer that has Windows 10 in it. When I bought the game it had Windows 8.1 and I was able to play the game. Now that I updated to Windows 10 the game won't start. This is the error message that I get: " GalaxyClient.exe-Bad Image C:\windows\system32\mfc110. dll is either not designed to run on windows or it contains an error. Try installing the program again using the original installation media or contact your system administrator or the software vendor for support. Error status 0xc0000020.". Does anyone else have this problem?

You could try to reinstall Visual C++ Redistributable for Visual Studio 2012 Update 4 package.
http://www.microsoft.com/en-us/download/details.aspx?id=30679&tduid=%28e357baf9ed40cdc85ed4a6824015e0db%29%28256380%29%282459594%29%28TnL5HPStwNw-bqtXSlf7ERBzUPLGdS9P1g%29%28%29
Download the Visual C++ Redistributable for Visual Studio 2012 Update 4 package and run it. This will replace/restore the mfc110.dll with the most recent copy provided by Microsoft.
If this is a GOG Galaxy problem you need the 32bit version if it is a Witcher 3 problem you need the 64bit version. If you aren`t sure install both.

Thanks but it didn't work at all. I did send in a support ticket to the software vender and they said the game was not tested with Windows 10.

Witcher 3 works on Windows 10. So this shouldn`t be the problem. Did you do an upgrade to Windows 10 or a clean install. If you do the first something could got messed up.
Back up your savegames just in case) and do a fresh install of GOG Galaxy and Witcher 3.

I upgraded to Windows 10. The GOG is looking for system 32 mfc 110.dll. My version of Windows 10 only has system 64. That may be the whole problem.

My advice: Try to repair your game with GOG Galaxy.
If this doesn`t help: Reinstall Witcher 3 with all patches and DLCs and see if this will fix it or do a clean install of Windows 10 and install Witcher 3 again with all patches and DLCs (Don`t forget to back up your savegames).

I found out what my problem is with GOG. The game requires a Nvidia GeForce GTX GPU or a AMD Radeon R9 290 GPU video cards. I have in my computer a Nvidia GTX 960. I thought that my video card was good enough to play The Witcher 3. But I guest wrong I think. I'm on limited income so I don't have the money to buy one of those video cards that are required. I want to thank all of you for your help.

GTX 960 is more than enough to run the game. I have GTX 760, a card older and slower than yours, and I'm on Windows 10 too, neither of these should cause any problem. The official minimum is GTX 660, so even one more generation older than mine.

I'd try to reinstall Galaxy and then reinstall the game. You could also try and see if the game launches directly from the .exe file (installation folder\bin\x64\witcher3.exe).

I got the game to play. I had to uninstall GOG Galaxy to get it to work. Thanks everyone for trying to help with the problem..