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I have played through this game multiple times, multiple ways since it was first released. After dropping it for other things (life...) I decided to load up on the latest EE version.

The game is really the same so far (I'm only in Act1) - but I really like the extra dialogue and explanations given to "flesh out" the story more completely. Great job.

Now, my point. Mutagen drops. When the game first came out I had no problem getting a Madness Mutagen or 2 simply by farming the Nekker cave in Flotsam, Act 1. After you cleared it multiple times, it became quite easy and was a great place to gain XP and money from the Nekker parts (especially after they nerfed my local ATM - Bart Bargee in the 1st patch, LOL). Subsequent patches seemed to have nerfed the Mutagen drops, as other "farming" playthroughs resulted in fewer Mutagens... and the Madness Mutagen seemed to be relegated to history for me.

So, on this playthrough, I'm doing much the same to make money and XP - farming the Nekker cave, and I get a Madness mutagen. Who-Hoo!. Next I take a run to grab the Osmark from the south cave. What do ya know - the Rotfiend drops another Madness Mutagen!

Did this latest patch re-align the Mutagen drops? Or is it simply good luck?

Anyway, it is nice to have such a re-playable game.
Nothing in the changelog about it, but I've noticed more mutagen drops. Maybe luck plays a role, but I got my first madness mutagen ever without farming on my first EE playthrough, not to mention a bunch of greater mutagens in quantities that would have been unthinkable in previous patch versions.

Madness mutagens are totally overrated, though. Greater power mutagens are where it's at.
Not that they are oh-so-powerful..., just that they are so rare, it seems like you have won something if you get one.

And I agree with you, Penguin, I think that overall, the Mutagen drops have been much higher in my EE playthough than before (with the exception of the original version).
People tell me only to use the Greater mutagens, and never lesser/normal

I ended up not using any mutagens the entire playthrough...
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Poohunter: People tell me only to use the Greater mutagens, and never lesser/normal

I ended up not using any mutagens the entire playthrough...
Pretty much the same here for every playthrough I've done. As you can't upgrade them it just seems a waste to use anything less than greater mutagens :/
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Poohunter: People tell me only to use the Greater mutagens, and never lesser/normal

I ended up not using any mutagens the entire playthrough...
Yeah same. I don't farm, and I struggle to get enough Greater mutagens to fill the slots.
Mutagens are hard to find now, it seems.

I use Side Effect from the Alchemy branch, but it seems to be a hit or miss. Sometimes it takes me 40+ potions just to get a ton of Lessers, it's frustrating having to reload and try over and over again for a specific mutagen.

I just run around the forests in Flotsam and gather as many ingredients as possible while farming enemies that spawn for the occasional mutagen drops, seems like the least time consuming method.