I have run Spore on win10, when enter the game, the screen only showed a galaxy which you can control by mouse, no responed to keybroad , there are no options to click to start the game. any advise will be great!!

Not sure.
Mine shows the galaxy. Never tried keyboard anyways. But, it shows my one game, plus 5 other "circles" in areas of the galaxy for "New Game".
My game auto signs in to Spore account. Not sure that is needed or not. Have you created an account or signed into one?

Do you use any odd fancy mouse software? Can conflict with older games (especially ones from DirectX8 era, DirectPlay)