fictrix: I've run into nearly all the bugs mentioned by Jonesy89, and a few others.

If you pick the "Novahot Targeting" skill for Blitz, he loses Mark Target and never gains Novahot Targeting, which is quite inconvenient.

Mind Wipe and Confusion (and another confusion-like skill that I won't spoil) still appear to be quite inconsistent, so use with caution. Even if you don't attack or damage the enemy you cast it on, they might turn on you immediately and forget they're supposed to ignore you/be on your side. I had this problem even before the Director's Cut, though.

You can't have more than 6 skill/spell/etc slots and this does break quite a few things. Players and NPCs who may have more than 6 spell/program slots now only have 6 slots. This means you have to be careful with Dietrich's loadout (because the totem counts towards the limit), and spoiler-NPC who dwells in the basement no longer has a ridiculous number of skills.

The 1 flashbang grenade in Eiger's inventory was sufficient for getting past her mission. I love the variety in the new missions and the additions to existing missions and dialogues. Even Eiger's one was quite puzzle-based (such as that particular sequence where you have to figure out the most efficient way to deal with the situation).

I'm up to the very last mission now and the bugs I've encountered have been inconvenient, but not game-breaking. I'm playing a face/mage/decker on Normal but I haven't run into any problems in combat, even on the missions where it's just you and 1 other companion.

There are some interesting new options at the end when you come face-to-face with the boss. I tried the worst possible one of curiosity, but as a non-combat character, there was no way I could survive the situation it puts you in, so I reloaded. Hah! It ends about as poorly as you might expect. When you get there, you'll know what I mean. I loved that the option was there, even though it's a no-win situation. I should have played it through to see if my death would result in a sarcastic epilogue scolding me for making such a poor choice (a la Bloodlines).

So, it's possible to ignore or work around all the bugs. If you prefer a smoother experience, it's best to wait for a patch.

[EDIT] And many things crash the Dragonfall Editor. Can't open scenes. Can't open dialogues. Lots of memory access violations everywhere.