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I've tried everything but I can't seem to get a fix,

If I run Sanitarium as downloaded from GOG, I get the rainbow colors glitch. The credits text at start is all blurring and rainbowy and the game itself has bad colors and glitches.

I've tried: Windows 95 Compatibility, Windows XP compatibility, run in 256 colors, etc. Nothing works. I've tried killing the explorer.exe process as indicated in some threads, still does it.

I've tried the Sanitarium HD Patcher in this thread and that does seem to work, however, the graphics are still glitchy with the edges bleeding everywhere and the graphics basically don't cover the whole screen.

I'm at a loss and really frustrated.

Any help?
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MBison: I've tried everything but I can't seem to get a fix,

If I run Sanitarium as downloaded from GOG, I get the rainbow colors glitch. The credits text at start is all blurring and rainbowy and the game itself has bad colors and glitches.

I've tried: Windows 95 Compatibility, Windows XP compatibility, run in 256 colors, etc. Nothing works. I've tried killing the explorer.exe process as indicated in some threads, still does it.

I've tried the Sanitarium HD Patcher in this thread and that does seem to work, however, the graphics are still glitchy with the edges bleeding everywhere and the graphics basically don't cover the whole screen.

I'm at a loss and really frustrated.

Any help?
I know this is old as fuck, but I had the same issue just now.

I tried to play using DxWnd and had the rainbow/distorted graphics, but it went back to normal if I tabbed out of the window and came back to it.
I know this is super late but for older games this is a great fix:
moddb.com/tutorials/mc-beginners-guide-rainbowcolor-issues-on-old-games