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All right, after some hard time getting everything to work as intended a new error popped up.
My mouse pointer leaves a trail after itself. It does however vanish if I "touch" an option in a dialogue or some other interactive object.

I have every mod installed that was recommended. My custom resolution is 1920x1080.
Could that be the cause?
This question / problem has been solved by YnKimage
Anything in these threads helps, or have you already tried that?

http://www.gog.com/forum/planescape_torment/cursor_trail
http://www.gog.com/forum/planescape_torment/pointer_trails
Thanks Ynk, the first link solved my problem :)