I've noticed two things that, while not game-breaking, are quite annoying. And one thing that is game breaking, but if you need to know about it ahead of time you can prevent it.

1) There seems to be an issue when characters attempt to cast a melee touch spell (spells like Cure x Wounds and Harm), where they ready the spell, but don;t actually cast it, even when in range. This is almost never an issue for enemies, I've only seen one enemy do this. Its usually my healers that ready the spell, and then need to cast it on their next turn (at least the slot isn't wasted).

2) Every now and then, I notice that the Quicksave and Autosave features don't fully save the game. Manually saving still works, and exiting and restarting the game seems to fix the issue.

3) Apparently, if you kill a certain party member after freeing Drezen in one of the houses, looting this party member's neck slot causes the game to load slowly whenevr transitioning into a new area, and even after reaching 100%, it doesn't actually load in. I say "apparently," because I read on another forum that not taking that piece of loot stops the bug from appearing, but I didn't know that until it was too late, as I had no saves that I hadn't already looted the item on, and needed to start the game over.

Otherwise, so far so good.

I can only speak to No 3.
Sorry to hear that you had to start over. A workaround seems to be to loot everything except for one item. I've had the same bug and going back to an earlier save then leaving some stuff one the body solved it for me.

1) Can be one of two. One of them is them to fail the cast - but that is easy to follow in the combat log. The other are known targeting issues which leads even to friendly fire. You could check whether it is the first or the second. For the second there cannot be done much besides submitting a bug report. It is definitely an issue which seems to be caused by how some spells works. As in: some spells needs to be charged first which takes half or a whole turn. But when the original target is neutralised by then sometimes it resolves properly, sometimes not. Currently no workaround known as far as I can tell.

2) An issue which can be seen often. It is suspected to be an individual issue due to the nature of how saving works. Though the game could be optimised as well in that regards. Same with loading issues almost the identical parameters matters. Whether the game is installed on HDD or SSD, and what Windows version (Home vs. Pro) people are using. When manual saving works it is an indicator that your gaming device cannot keep up by how the game saves when it does a quick one. Especially when it happens while your party is currently doing something/there are calculation processes still running in the background.

3) Known issue. Should be fixed / addressed already. Eventually the latest version of the game helps. Known workaround - though unconfirmed - adding a companion either via Pathfinder society or ToyBox (mod). Reasoning: it has something to do with the companion's corpse in general and less with that specific companion in your case. The issue can be observed in other cases as well in which you decide to kill off a companion. A workaround by the developers to prevent that for a while had been to deactivate lootable corpses of companions. Which lead to different issues. The workaround is lacking confirmation since the majority I have seen who have resolved it are using mods. And it is hard to tell how much the mod was responsible for the fix since it adds additional variables.

A lot of mod users think it is no big deal, but with one of the last patch when the developers adjusted some enemies' stats, a certain mod caused all enemies to be as squishy as level 1.

Thanks for sharing your experiences with us. The third bug I would already consider as game breaking. It would interest me if the mentioned workaround with the mod would have fixed it.

I have noticed quite a few more than three. As to those mentioned I can absolutely confirm number one. It is incredibly annoying and entirely one sided.

Having said that, I also have numerous instances of giving commands to units in turn based which fail to follow through. Rushing seems to be the worst, rushing from stealth doesn't seem to work at all and simply results in a wasted action but I am not entirely sure if that is intended or not so that may be set aside, but even out of stealth and in the middle of combat trying to use it to close the gap between assailants seems to result in no action and a skipped turn something like five to ten percent of the time.

Even normal attacks sometimes result in nothing, though far less frequently. I have tried to swing at an opponents directly in front of a character, which had not phased in that turn (on that topic, not being able to target enemies clearly on the battlefield because they *just* joined combat is atrociously suspect design choice), only to see no attack registered in the log, my attack button greyed out, and left only with move actions to end my turn. Still, this is not nearly as annoying as party members, rarely granted, having their turns skipped entirely.

One would think with combat filling the overwhelming majority of play time that it at least would run flawlessly.

Balance issues and bugs taken together, this title really needed a few more months of fine tuning prior to launch. I have had to restart a single play through numerous times due to broken Mythic paths (looking at you Golden Dragon) to absolutely broken Crusade mode nonsense. It seems mostly stable at the moment with most of what I am running into falling into the annoying-but-manageable rather than gamebreakingly-bad category but I am pretty close to shelving this until next year. Loving this game takes a real effort.

Reporting such bugs with the Alt+B function will hopefully bring them to the attention of the devs.