I'm running Infernal Machine on Win10. I got through the cutscene at the end of level 1 fine the first time, but every time I play it since then the game freezes part way through. I tried reducing the resolution then loading the game from quicksave but it still froze. Anyone have any ideas?

It sounds like a corrupt installation. I would use GOG's repair option, or uninstal and then reinstall the game. Also update the drivers for your video and audio cards.