https://www.nexusmods.com/newvegas/mods/62552?tab=description

New update for 4gb patcher:

Version 1.4
- Added patching the GoG version to load NVSE automatically.
- Yes we know it is LAA enabled by default.

This is pretty good thing, for GoG users. Can just start with launcher, no need launch via NVSE. So, if you use GoG version and NVSE, it is very recommend to use this newest patch with it.

There seem to be problems with one of these things and this 4gb patcher version 1.4 (during gameplay or starting game)

Bitdefender antivirus + New California mod (don't allow game saving)
ENB (black screen when starting FNV, doesn't disappear even after waiting quite while)

Vanilla FNV should work just fine + with mods that doesn't change game dramatically.

GOG version of FNV is 4GB aware already. No need for patch.