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I ask because I like the game, but loadings are terrible.
And its tied to fps or something and when I fixed it with unnoficial patch, it basically messed up whole logic of the game.

I would buy this if they made the effort to fix it, but... they didn't, right?
I'm interested in this too, mostly for modding purposes. Bethesda loves to just drop patches that do nothing but break every mod.
One of the reason why Skyrim broke in the first place was because the gog version save preferences are inside
Documents\My Games\Skyrim Special Edition GOG
instead of
Documents\My Games\Skyrim Special Edition

for Fallout 4 this is not true at all
Documents\My Games\Fallout4

is the preferences folder for gog version too.

I just tried F4SE in combination with High FPS Physics Fix mod and it just works without a problem (and the version of the game is the same
1.10.163.0
at least that's why High FPS Physics Fix mod require)
Thanks!
Yeah, thanks LiefLayer.
But also, this is not the same version. This doesn't have access to the in-game Creation store. That's a good thing in my opinion, but still a big difference.
Nexus Mods has a FAQ concerning differences with the GOG release... it's a good read. Just Google "Fallout 4 gog".
Here's the link to the article on Nexus mods.

https://www.nexusmods.com/news/14871