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bombe_zwanzig: I tried to play vanilla right now, cause i know it's buggy under win7, but the lines in the fallout .ini which alter the multicore-behaviour have been changed by GOG already. it should run. should. hmpf.

edith reminds me: i also changed compatibility to xp sp3 and gave admin rights.
it happened to me once on my own (not testlab) machine - I had to switch to windowed mode for initial boot and after that it was safe to play in fullscreen.

but I couldn't get a reliable repro and my PC has lots of weird stuff floating around, so I just ignored it.
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bombe_zwanzig: [..]
then we will have to go into details ;)

any previous installations, at any point?
if you have any .INI in Documents\My Games\Fallout 3, remove them
if you have any plugins active, disable anything except .ESMs (that includes *language*.esp, if present)
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bombe_zwanzig: the old savegames and inis seem to cause these problems...
that is an unfortunate truth for all these Gamebryo games ;)
But I'm glad it worked so fast for you.