EVERY FIFTEEN MINUTES
CTD
CTD
CTD
CTD
Fraud. Ripoff. Fraud. Ripoff. Fraud. Ripoff/

Useful information about your system and install procedure could result in a solution to your problem. Breaking down in tears wont.
On a fresh install of the post-patch gog version I enjoy consecutive hours of gameplay. The only time I've ever crashed was when alt-tabbing too often.
I used Microsoft Application Compatibility Toolkit 5 to force single processor affinity to resolve sound static with my on-board audio device but other than that, game is running fine.
Have you even tried to diagnose the problem yourself? Turn all the visual settings off/to low and see if you can play longer. At higher resolutions memory use multiplies exponentially.

If you are still crashing, refer to this post.

I had one crash with the previous version of DD and none with the latest one.
As well as the previous suggestions, have you tried disabling the background tasks that can cause problems in other games - these include anti-virus utilities, malware sniffers and the ATI Catalyst Control Center.
The only ongoing problem I had was sound static, which was resolved using Runfirst.

What's Runfirst? I got the sound static thing going on. The new version fixed my CTD problems, though, which was awesome.

RunFirst is a small program that automagically sets the Affinity to the first CPU. Worked for my static as well.
The trick was getting the command line right - mine is as follows -
"C:\Program Files\GOG.com\RunFirst\RunFirst.exe" "C:\Program Files\GOG.com\Divine Divinity\div.exe"
Note that both paths are enclosed in quotes with a space between the two paths.
You can put the RunFirst.exe anywhere, I just created a directory under my GOG install directory called RunFirst and added the path to the beginning of the shortcut target path.

Thanks!