I'm on my third classic play through and this time around, trying to follow the logical path in the murder investigation, I didn't speak to Leandra (in case I got the name wrong, the medical apprentice) until after suspicisn of her was triggered by Jake's wife. So, when I arrived for the first time, she was gone. I assume that kills the two patients side quest (c'est la vie) but I am wondering about the blood stone. I know that in the long run, there are far more stones then doors at the edge of time so missing it is not significant, but, just for curiosity's sake, will it show up later?