Alt-F4 or Ctrl-Alt-Del don't help when the game freezes?

When you tried running as administrator, was that with the Galaxy client shut down, and starting the game directly from the '..\Divinity Original Sin Enhanced Edition\Shipping\EoCApp.exe' program file?

Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls have also caused conflicts on startup, though that should be less likely with an exception added for the game. Overlays from graphics tweaking/monitoring programs or chat programs have caused issues.

If you have any old or obscure USB controllers (or other devices) plugged in, try disconnecting them. Crashes on startup with faulting module names of ntdll.dll and EZFRD64.DLL, can (particularly for the latter) be related to USB controllers or PS2 to USB adapters (for various games). I don't think this has been related to freezing, but it's worth checking.

You can try lowering your desktop refresh rate, and see if that makes a difference.

Check for updated graphics drivers and Windows updates in general.

Try manually installing the support packages (from the __redist folder in the game install folder) and reboot.

If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might help identify the problem? It probably won't, though, since it is freezing and requiring a hard reboot.
- click Start (or WinKey-R), then type "event viewer" into the search box. in Windows 10, 'event' should bring up 'View event logs'.
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error (maybe sort by Date and Time) for the game
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."


Try browsing to the '..\Documents\Larian Studios' folder and deleting the 'Divinity Original Sin Enhanced Edition' subfolder, if the game is getting far enough in the startup process to create it.
This folder contains the saved games, configuration files and a level cache folder. Normally I would suggest renaming the folder for troubleshooting purposes, but if you don't have any saved games that isn't an issue.
Next, extract the replacement folder from this download into your '..\Documents\Larian Studios' folder (create the Larian Studios folder if necessary), and see if that will let you start the game (it may help if the problem is in setting up the initial My Documents folder and configuration files).

The graphicSettings.lsx file is set to 1280x720 Windowed mode, Very Low quality preset, which you can change in the options (manually, or hit autodetect) if this gets the game to start.
If that doesn't help, you can delete the downloaded My Documents D:OS folder.