I know for a FACT that the D2X-XL source port allows this (in addition to many, many other things). I haven't used it though, I chose DXX Rebirth because I'm too lazy to set up D2X-XL and the mostly classic experience is good enough for me.
I'm actually thinking about getting back into Descent again and trying D2X-XL because it looks so cool. It's more analogous to the Freespace Open project than a simple source port like Rebirth (except it's no where near as well organized or staffed. The FSO guys have plenty of people working together on multiple projects and they have clarity and documentation down to a science).