I got to the point in "The Nomad" where V and Jackie open the cargo and find the lizard. Right when V shakes Jackie's hand, the game crashes. This is repeatable and happens every time.

Processor Intel(R) Core(TM) i5-10600K CPU @ 4.10GHz 4.10 GHz
Installed RAM 16.0 GB
System type 64-bit operating system, x64-based processor
Radeon RX 5500 XT (6 GB RAM)

Edit: Nevermind. New video card driver version fixed it.