I would really like to play Blood 2, but I'd rather not bother with it if it's just going to lock my computer or crash to desktop every ten minutes. I was hoping that folks who are playing it now could comment on the stability of it. Of course, everyone's system will produce different results, but I'm wondering if most people find it stable enough to justify a purchase.

I dont seem to have the random crashing that others have mentioned. The game will crash with the MFC error at certain high resolutions. I am running at 1280x960 with no problems.
1280x1024 caused me to crash alot.
Windows XP SP3
4gb RAM
GeForce 9500GT
I am not using any compatability settings

Except for some video flickering here and there, it has been running very smooth for me on XP, Vista / Vista-64, and 7

Client MFC has stopped working. My current error which pops up either randomly through gameplay or right when starting a game. Im sure the gog staff will get to the bottom of this!
Ps: I remember fixing this error before. I know its fixable, but, I cant find it...

I'd struggle to recommend it if weathering crash after crash is an issue, at least on my Win7 64bit box.

Sadly I can't even run Blood 2 on my system. Win7 with dual core.

Works great on my system, gog version.
Installed to D:\ drive.
Playing in hardware mode, at 1600x900.
I got 1 mfc crash, and that was because the resolution was too high (tried native res of 1680x1050), and I didnt reboot after installing.
Not a single crash since then, even in the museum.
And the original disk version always crashed on me and I could only run it in software mode, and nothing above 800x600.
Just like the original, it seems it is a crap-shoot on which system it will work will on.
But, most older games run well in XP, and arent so hot in Vista/Win 7.
This is because MS took out the direct software to hardware communication layer, for 'security' reasons. Not to mention no dos support.
My specs:
E8600 3.33ghz (no oc) dual core
4gb memory ddr3
GTX280 (no oc)
8800gt phys-x card
X-FI gamer sound card in 5.1
XP 64 bit sp2

You can fix that with setting a MaxFps for the game. If that alone doesn't fix it you can tick few settings in the advanced launcher menu.

My experience thus far, has been that after setting the resolution lower
1600 x 900
and binding the EXE to a single core, I have not seen another single MFC error.
Note that I'm currently in the museum level, so hard to say what will happen once I get through it.