Yeah. better use 2\3 display devices. Smartphone\Tablet maybe?
I dont think that game can be run in any windowed mode. This is Win9x game, time when it be more critical to not alt-tab\minimize games. Currently for just play you can download and use GOG build as is - with they own wrapper. But there is another one mod-wrapper (more than just compatibility thing, but most authentic way to play PC version, without replacing exe file - best way to play before GOG release) - Glwrapper from Verok. And for streaming process we can named this mod as necessary for streaming this game. Same as other games wrappers from Verok. Very cool works, especially for streamers with fast alt-tab and borderlesswindowed mode (actually it alwas work in borderless widnowed or windowed - no native fullscreen, so resolution\refreshrate\vsync from Desktop will be used).
http://www.gog.com/forum/blood_omen_legacy_of_kain/veroks_gl_wrapper_patch http://verokster.blogspot.com/
Also, can be useful:
[url=http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain]http://www.pcgamingwiki.com/wiki/Blood_Omen:_Legacy_of_Kain[/url]